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Nutritional Formula Improves Cognitive Performance

A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension
Authors: Remington, Ruth | Lortie, Jevin J. | Hoffmann, Heather | Page, Robert | Morrell, Christopher | Shea, Thomas B.
Abstract: Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline performance in CLOX-1. The placebo cohort did not improve in DRS and declined in CLOX-1, but during the open-label extension improved in DRS and ceased declining in CLOX-1. These findings extend prior studies of NF efficacy for individuals without cognitive impairment and with Alzheimer’s disease.
Keywords: Aging, Alzheimer’s disease, cognitive performance, dementia, mild cognitive impairment, nutraceutical
DOI: 10.3233/JAD-150057
Citation: Journal of Alzheimer's Disease, vol. 48, no. 3, pp. 591-595, 2015

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